COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear.. ..Between 11 and 29 March 2020, 79 patients with IBD with COVID-19 were enrolled… Continue reading Outcomes of COVID-19 in 79 patients with #IBD in Italy: an IG-IBD study
Tag: IBD
IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed #vascular barrier disruption
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with rising incidence. Diseased tissues are heavily vascularized ..Specifically, we show that inhibition of the IFN-γ response in vessels by endothelial-specific knockout of IFN-γ receptor 2 ameliorates experimentally induced colitis in mice. IFN-γ acts pathogenic by causing a breakdown of the vascular barrier through disruption of… Continue reading IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed #vascular barrier disruption
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