We report the kinetics of immune responses in relation to clinical and virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) that required hospitalization. Increased antibody-secreting cells (ASCs), follicular helper T cells (TFH cells), activated CD4+ T cells and CD8+ T cells and immunoglobulin M (IgM) and IgG antibodies that bound the COVID-19-causing… Continue reading Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe #COVID-19
Tag: coronavirus
Characteristics and Outcomes of 21 Critically Ill Patients With #COVID-19 in Washington State
..A total of 21 cases were included (mean age, 70 years [range, 43-92 years]; 52% male). Comorbidities were identified in 18 cases (86%), with chronic kidney disease and congestive heart failure being the most common. Initial symptoms included shortness of breath (76%), fever (52%), and cough (48%) (Table 1). The mean onset of symptoms prior… Continue reading Characteristics and Outcomes of 21 Critically Ill Patients With #COVID-19 in Washington State
A Trial of #Lopinavir–#Ritonavir in Adults Hospitalized with Severe #Covid-19
..Treatment with lopinavir–ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical improvement, 1.24; 95% confidence interval [CI], 0.90 to 1.72). Mortality at 28 days was similar in the lopinavir–ritonavir group and the standard-care group (19.2% vs. 25.0%; difference, −5.8 percentage points; 95% CI, −17.3… Continue reading A Trial of #Lopinavir–#Ritonavir in Adults Hospitalized with Severe #Covid-19
Aerosol and Surface Stability of #SARS-CoV-2 as Compared with SARS-CoV-1
..SARS-CoV-2 remained viable in aerosols throughout the duration of our experiment (3 hours), with a reduction in infectious titer from 103.5 to 102.7 TCID50 per liter of air. This reduction was similar to that observed with SARS-CoV-1, from 104.3 to 103.5 TCID50 per milliliter (Figure 1A). SARS-CoV-2 was more stable on plastic and stainless steel… Continue reading Aerosol and Surface Stability of #SARS-CoV-2 as Compared with SARS-CoV-1
Risk Factors Associated With Acute #Respiratory Distress Syndrome and Death in Patients With #Coronavirus Disease 2019 Pneumonia in Wuhan, China
Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been well delineated.. ..Of 201 patients, the median age was 51 years (interquartile range, 43-60 years), and 128 (63.7%) patients were men.… Continue reading Risk Factors Associated With Acute #Respiratory Distress Syndrome and Death in Patients With #Coronavirus Disease 2019 Pneumonia in Wuhan, China
Relationship between the ABO #Blood Group and the #COVID-19 Susceptibility
Detection of ABO blood groups, infection occurrence of SARS-CoV-2, and patient death RESULTS The ABO group in 3694 normal people in Wuhan showed a distribution of 32.16%, 24.90%, 9.10% and 33.84% for A, B, AB and O, respectively, versus the distribution of 37.75%, 26.42%, 10.03% and 25.80% for A, B, AB and O, respectively, in… Continue reading Relationship between the ABO #Blood Group and the #COVID-19 Susceptibility
Critical Care Utilization for the #COVID-19 Outbreak in Lombardy, Italy Early Experience and Forecast During an Emergency Response
On February 20, 2020, a patient in his 30s admitted to the intensive care unit (ICU) in Codogno Hospital (Lodi, Lombardy, Italy) tested positive for a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). He had a history of atypical pneumonia that was not responding to… Continue reading Critical Care Utilization for the #COVID-19 Outbreak in Lombardy, Italy Early Experience and Forecast During an Emergency Response
Clinical course and risk factors for mortality of adult inpatients with #COVID-19 in Wuhan, China: a retrospective cohort study
Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described..… Continue reading Clinical course and risk factors for mortality of adult inpatients with #COVID-19 in Wuhan, China: a retrospective cohort study
Consistent Detection of 2019 Novel #Coronavirus in #Saliva
The 2019 novel coronavirus (2019-nCoV) was detected in the self-collected saliva of 91.7% (11/12) of patients. Serial saliva viral load monitoring generally showed a declining trend. Live virus was detected in saliva by viral culture. Saliva is a promising noninvasive specimen for diagnosis, monitoring, and infection control in patients with 2019-nCoV infection. https://bit.ly/399IDoR PDF file… Continue reading Consistent Detection of 2019 Novel #Coronavirus in #Saliva
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