IntroductionRecent evidence suggests that oxidative stress and endothelial dysfunction play critical roles in the pathophysiology of COVID-19 and Long-COVID. We hypothesized that a supplementation combining L-Arginine (to improve endothelial function) and Vitamin C (to reduce oxidation) could have favorable effects on Long-COVID symptoms.MethodsWe designed a survey (LINCOLN: L-Arginine and Vitamin C improves Long-COVID), assessing several symptoms that have been associated with Long-COVID to be administered… Continue reading Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey
Category: Infectivology
Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population
The coronavirus disease 2019 (COVID-19) has been a challenge for the whole world since the beginning of 2020, and COVID-19 vaccines were considered crucial for disease eradication. Instead of producing classic vaccines, some companies pointed to develop products that mainly function by inducing, into the host, the production of the antigenic protein of SARS-CoV-2 called… Continue reading Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population
Physical interventions to interrupt or reduce the spread of respiratory viruses
...We included 11 new RCTs and cluster‐RCTs (610,872 participants) in this update, bringing the total number of RCTs to 78. Six of the new trials were conducted during the COVID‐19 pandemic; two from Mexico, and one each from Denmark, Bangladesh, England, and Norway. We identified four ongoing studies, of which one is completed, but unreported, evaluating masks… Continue reading Physical interventions to interrupt or reduce the spread of respiratory viruses
Mask mandate and use efficacy for COVID-19 containment in US States
Background: COVID-19 pandemic mitigation requires evidence-based strategies. Because COVID-19 can spread via respired droplets, most US states mandated mask use in public settings. Randomized control trials have not clearly demonstrated mask efficacy against respiratory viruses, and observational studies conflict on whether mask use predicts lower infection rates. We hypothesized that statewide mask mandates and mask… Continue reading Mask mandate and use efficacy for COVID-19 containment in US States
Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
BACKGROUND:Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these individuals have not been described in detail.METHODS:From January 2021 through February 2022, we prospectively collected blood from 16 patients who were hospitalized at Massachusetts General… Continue reading Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
BACKGROUND:Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these individuals have not been described in detail.METHODS:From January 2021 through February 2022, we prospectively collected blood from 16 patients who were hospitalized at Massachusetts General… Continue reading Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
Unravelling the role of the mandatory use of face covering masks for the control of SARS-CoV-2 in schools: a quasi-experimental study nested in a population-based cohort in Catalonia (Spain)
Objective To assess the effectiveness of mandatory use of face covering masks (FCMs) in schools during the first term of the 2021–2022 academic year.Design A retrospective population-based study.Setting Schools in Catalonia (Spain).Population 599 314 children aged 3–11 years attending preschool (3–5 years, without FCM mandate) and primary education (6–11 years, with FCM mandate).Study period From 13 September to 22 December 2021… Continue reading Unravelling the role of the mandatory use of face covering masks for the control of SARS-CoV-2 in schools: a quasi-experimental study nested in a population-based cohort in Catalonia (Spain)
Censorship and Suppression of Covid-19 Heterodoxy: Tactics and Counter-Tactics
The emergence of COVID-19 has led to numerous controversies over COVID-related knowledge and policy. To counter the perceived threat from doctors and scientists who challenge the official position of governmental and intergovernmental health authorities, some supporters of this orthodoxy have moved to censor those who promote dissenting views. The aim of the present study is… Continue reading Censorship and Suppression of Covid-19 Heterodoxy: Tactics and Counter-Tactics
Age-stratified infection fatality rate of COVID-19 in the non-elderly population
The largest burden of COVID-19 is carried by the elderly, and persons living in nursing homes are particularly vulnerable. However, 94% of the global population is younger than 70 years and 86% is younger than 60 years. The objective of this study was to accurately estimate the infection fatality rate (IFR) of COVID-19 among non-elderly… Continue reading Age-stratified infection fatality rate of COVID-19 in the non-elderly population
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