The case of a patient who experienced two facial palsies - one after the first and another after the second dose of the Pfizer-BioNTech COVID-19 vaccine - strongly suggests that Bell's palsy (facial nerve palsy of unknown cause) is linked to the Pfizer-BioNTech vaccine, doctors write in the journal BMJ Case Reports. They describe the… Continue reading Patient case strongly suggests link between #COVID-19 vaccine and #Bell’s palsy
Category: Infectivology
#Cardiovascular drugs and #COVID-19 clinical outcomes: A living systematic review and meta-analysis
The aim of this study was to continually evaluate the association between cardiovascular drug exposure and COVID-19 clinical outcomes (susceptibility to infection, disease severity, hospitalization, hospitalization length, and all-cause mortality) in patients at risk of/with confirmed COVID-19. MethodsEligible publications were identified from more than 500 databases on 1 November 2020. One reviewer extracted data with… Continue reading #Cardiovascular drugs and #COVID-19 clinical outcomes: A living systematic review and meta-analysis
#COVID-19 #vaccine efficacy and effectiveness—the elephant (not) in the room
Approximately 96 COVID-19 vaccines are at various stages of clinical development.1 At present, we have the interim results of four studies published in scientific journals (on the Pfizer–BioNTech BNT162b2 mRNA vaccine,2 the Moderna–US National Institutes of Health [NIH] mRNA-1273 vaccine,3 the AstraZeneca–Oxford ChAdOx1 nCov-19 vaccine,4 and the Gamaleya GamCovidVac [Sputnik V] vaccine)5 and three studies… Continue reading #COVID-19 #vaccine efficacy and effectiveness—the elephant (not) in the room
#Baricitinib reduces 30-day mortality in older adults with moderate-to-severe #COVID-19 pneumonia
Older adults are at the highest risk of severe disease and death due to COVID-19. Randomized data have shown that baricitinib improves outcomes in these patients, but focused stratified analyses of geriatric cohorts are lacking. Our objective was to analyze the efficacy of baricitinib in older adults with COVID-19 moderate-to-severe pneumonia. MethodsThis is a propensity… Continue reading #Baricitinib reduces 30-day mortality in older adults with moderate-to-severe #COVID-19 pneumonia
Deaths in Children and #Young People in England following #SARS-CoV-2 infection during the first pandemic year: a national study using linked mandatory child death reporting data
This is a preprint. It has not completed peer review. Background Deaths in children and young people (CYP) following SARS-CoV-2 infection are rare. Quantifying the risk of mortality is challenging because of high relative prevalence of asymptomatic and non-specific disease manifestations. Therefore, it is important to differentiate between CYP who have died of SARS-CoV-2 and… Continue reading Deaths in Children and #Young People in England following #SARS-CoV-2 infection during the first pandemic year: a national study using linked mandatory child death reporting data
Auto-immune #hepatitis following #COVID vaccination
Unprecedented loss of life due to the COVID pandemic has necessitated the development of several vaccines in record time. Most of these vaccines have received approval without being extensively whetted for their adverse effect and efficacy profiles. Most adverse effects have been mild, nonetheless, more serious thromboembolic events have also been reported. Autoimmune hepatitis (AIH)… Continue reading Auto-immune #hepatitis following #COVID vaccination
SO-25 Global rise in early-onset #colorectal cancer: An association with #antibiotic consumption?
Since the late 1980s, global antibiotic consumption and colorectal cancer (CRC) rates in those aged less than 50 years have soared. As the gut microbiome modulates many human processes, significantly altering microbiome structure and diversity with antibiotic therapy has previously been shown to influence CRC genesis in older adults. To our knowledge, no study before… Continue reading SO-25 Global rise in early-onset #colorectal cancer: An association with #antibiotic consumption?
A 5,000-year-old hunter-gatherer already plagued by #Yersinia pestis
A 5,000-year-old Yersinia pestis genome (RV 2039) is reconstructed from a hunter-fisher-gatherer (5300–5050 cal BP) buried at Riņņukalns, Latvia. RV 2039 is the first in a series of ancient strains that evolved shortly after the split of Y. pestis from its antecessor Y. pseudotuberculosis ∼7,000 years ago. The genomic and phylogenetic characteristics of RV 2039… Continue reading A 5,000-year-old hunter-gatherer already plagued by #Yersinia pestis
An #Egg-Derived Sulfated N-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus #Vaccines
Influenza viruses grown in eggs for the purposes of vaccine generation often acquire mutations during egg adaptation or possess different glycosylation patterns than viruses circulating among humans. Here, we report that seasonal influenza virus vaccines possess an egg-derived glycan that is an antigenic decoy, with egg-binding MAbs reacting with a sulfated N-acetyllactosamine (LacNAc). Half of… Continue reading An #Egg-Derived Sulfated N-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus #Vaccines
2 Medical News 