Background: Ivermectin suppresses tumor growth in various cancers. However, the mechanism of action in cancer remains unclear. This study aimed to investigate the anticancer activity of ivermectin against gastric cancer cell lines and patient-derived organoids.Methods: Cell viability was measured in SNU719 and SNU620 gastric cancer cell lines. Protein expression levels of apoptosis-related markers were analyzed… Continue reading Tumor growth suppression of ivermectin in gastric cancer cell lines and primary gastric cancer organoids
Tag: ivermectin
Effectiveness of ivermectin-based multidrug therapy in severely hypoxic, ambulatory COVID-19 patients
Aims: Ivermectin is a safe, inexpensive and effective early COVID-19 treatment validated in 20+ random, controlled trials. Having developed combination therapies for Helicobacter pylori, the authors present a highly effective COVID-19 therapeutic combination, stemming from clinical observations. Patients & methods: In 24 COVID-19 subjects refusing hospitalization with high-risk features, hypoxia and untreated moderate to severe… Continue reading Effectiveness of ivermectin-based multidrug therapy in severely hypoxic, ambulatory COVID-19 patients
Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching
ORIGINAL ARTICLE PEER-REVIEWED Background: Ivermectin has demonstrated different mechanisms of action that potentially protect from both coronavirus disease 2019 (COVID-19) infection and COVID-19-related comorbidities. Based on the studies suggesting efficacy in prophylaxis combined with the known safety profile of ivermectin, a citywide prevention program using ivermectin for COVID-19 was implemented in Itajaí, a southern city… Continue reading Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching
Ivermectin prophylaxis used for COVID-19 reduces COVID-19 infection and mortality rates: A 220,517-subject, populational-level retrospective citywide
Background: Ivermectin has demonstrated different mechanisms of actions that could potentially protect from both COVID-19 infection and COVID-19-related comorbidities. Based on the existing literature and safety profile of ivermectin, a citywide program of prophylactic use of ivermectin for COVID-19 was implemented in Itajai, a Southern city in Brazil in the state of Santa Catarina. The… Continue reading Ivermectin prophylaxis used for COVID-19 reduces COVID-19 infection and mortality rates: A 220,517-subject, populational-level retrospective citywide
#Ivermectin for Prevention and Treatment of #COVID-19Infection: A Systematic Review, Meta-analysis, and TrialSequential Analysis to Inform Clinical Guidelines
Background: Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasiticivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials. Areas of uncertainty: We assessed the efficacy of ivermectin treatment in reducing mortality, in secondary outcomes, and in chemoprophylaxis, among people with, or at high risk of, COVID-19 infection.… Continue reading #Ivermectin for Prevention and Treatment of #COVID-19Infection: A Systematic Review, Meta-analysis, and TrialSequential Analysis to Inform Clinical Guidelines
Favorable outcome on viral load and culture viability using #Ivermectin in early treatment of non-hospitalized patients with mild #COVID-19 – A double-blind, randomized placebo-controlled trial
Ivermectin, an anti-parasitic agent, also has anti-viral properties. Our aim was to assess whether ivermectin can shorten the viral shedding in patients at an early-stage of COVID-19 infection. Methods The double-blinded trial compared patients receiving ivermectin 0·2 mg/kg for 3 days vs. placebo in non-hospitalized COVID-19 patients. RT-PCR from a nasopharyngeal swab was obtained at… Continue reading Favorable outcome on viral load and culture viability using #Ivermectin in early treatment of non-hospitalized patients with mild #COVID-19 – A double-blind, randomized placebo-controlled trial
Review of the Emerging Evidence Demonstrating the Efficacy of #Ivermectin in the Prophylaxis and Treatment of #COVID-19
This is a provisional file, not the final typeset article Article.pdfDownload
#Ivermectin for Prevention and Treatment of #COVID-19 InfectionA Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines
Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials. Areas of uncertainty:We assessed the efficacy of ivermectin treatment in reducing mortality, in secondary outcomes, and in chemoprophylaxis, among people with, or at high risk of, COVID-19 infection. Data… Continue reading #Ivermectin for Prevention and Treatment of #COVID-19 InfectionA Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines