Opioid analgesics are commonly used for acute low back pain and neck pain, but supporting efficacy data are scarce. We aimed to investigate the efficacy and safety of a judicious short course of an opioid analgesic for acute low back pain and neck pain.MethodsOPAL was a triple-blinded, placebo-controlled randomised trial that recruited adults (aged ≥18… Continue reading Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial
Tag: placebo
#Placebos without deception reduce self-report and neural measures of emotional #distress
Several recent studies suggest that placebos administered without deception (i.e., non-deceptive placebos) can help people manage a variety of highly distressing clinical disorders and nonclinical impairments. However, whether non-deceptive placebos represent genuine psychobiological effects is unknown. Here we address this issue by demonstrating across two experiments that during a highly arousing negative picture viewing task,… Continue reading #Placebos without deception reduce self-report and neural measures of emotional #distress
The influence of #personality traits on the #placebo/nocebo response: A systematic review
Some people might be more prone to placebo and nocebo responses than others depending on their personality traits.. After screening 407 references, we identified 24 studies. The Big Five (i.e., neuroticism, extraversion, openness to experience, agreeableness and conscientiousness) and optimism were the most frequently investigated personality traits. Several studies found a positive association between optimism… Continue reading The influence of #personality traits on the #placebo/nocebo response: A systematic review
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