The massed-spaced effect is a hallmark feature of memory formation. We now demonstrate this effect in two separate non-neural, immortalized cell lines stably expressing a short-lived luciferase reporter controlled by a CREB-dependent promoter. We emulate training using repeated pulses of forskolin and/or phorbol ester, and, as a proxy for memory, measure luciferase expression at various… Continue reading The massed-spaced #learning effect in non-neural human #cells
Tag: cells
Human #cells experience a #Zn2+ pulse in early G1
Highlights•Human cells experience a transient zinc pulse in early G1•The magnitude of the pulse tracks with the amount of zinc in the cytosol and media•Knockdown of MTF-1 decreases metallothionein and increases the zinc pulse•Cells pause proliferation until labile cellular zinc is in the optimum range SummaryZinc is an essential micronutrient required for all domains of… Continue reading Human #cells experience a #Zn2+ pulse in early G1
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