To summarise systematic reviews on tobacco addiction published by the Cochrane Tobacco Addiction Group (CTAG) from 2021 to 2023.MethodsWe identified all new and updated Cochrane Reviews published by CTAG between 2021 and 2023. We present key results from these reviews and discuss promising avenues for future research.ResultsCTAG published five new reviews and one overview of… Continue reading Effects of interventions to combat #tobacco addiction: #Cochrane update of 2021 to 2023 reviews
Tag: addiction
Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for #heroin use disorder
The current opioid epidemic necessitates a better understanding of human addiction neurobiology to develop efficacious treatment approaches. Here, we perform genome-wide assessment of chromatin accessibility of the human striatum in heroin users and matched controls. Our study reveals distinct neuronal and non-neuronal epigenetic signatures, and identifies a locus in the proximity of the gene encoding… Continue reading Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for #heroin use disorder
#Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain
Excessive sucrose consumption elicits addiction-like craving that may underpin the obesity epidemic. Opioids and dopamine mediate the rewarding effects of drugs of abuse, and of natural rewards from stimuli such as palatable food.. ..After 12 days of sucrose access, BPND of both tracers had declined significantly in striatum, nucleus accumbens, thalamus, amygdala, cingulate cortex and… Continue reading #Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain
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