Objective To characterise the clinical features of monkeypox infection in humans.Design Descriptive case series.Setting A regional high consequences infectious disease centre with associated primary and secondary care referrals, and affiliated sexual health centres in south London between May and July 2022.Participants 197 patients with polymerase chain reaction confirmed monkeypox infection.Results The median age of participants… Continue reading Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series
Category: Infectivology
Clinical efficacy and safety of linezolid in intensive care unit patients
AbstractBackgroundTo characterize the population of critically ill patients and infections treated with linezolid in the intensive care unit (ICU), and to evaluate the clinical efficacy and safety of linezolid therapy.MethodsThis multi-center, observational, real-world study was conducted across 52 hospitals between June 9, 2018, and December 28, 2019. Patients who met the following inclusion criteria were… Continue reading Clinical efficacy and safety of linezolid in intensive care unit patients
Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination
COVID-19 mRNA vaccines effectively reduce incidence of severe disease, hospitalisation and death. The biodistribution and pharmacokinetics of the mRNA-containing lipid nanoparticles (LNPs) in these vaccines are unknown in humans. In this study, we used qPCR to track circulating mRNA in blood at different time-points after BNT162b2 vaccination in a small cohort of healthy individuals. We… Continue reading Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination
Effects of wearing FFP2 masks on SARS-CoV-2 infection rates in classrooms
Importance: Different mitigation measures are mandated in schools worldwide to control the spread of SARS-CoV-2. The efficacy of most measures, however, has not been investigated thus far. Objective: To investigate the usefulness of FFP-2 masks in classrooms to prevent the spread of SARS-CoV-2. Design: A retrospective comparative cohort study of infection rates (evaluated by PCR… Continue reading Effects of wearing FFP2 masks on SARS-CoV-2 infection rates in classrooms
Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022
Before April 2022, monkeypox virus infection in humans was seldom reported outside African regions where it is endemic. Currently, cases are occurring worldwide. Transmission, risk factors, clinical presentation, and outcomes of infection are poorly defined.METHODSWe formed an international collaborative group of clinicians who contributed to an international case series to describe the presentation, clinical course,… Continue reading Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022
Transient and durable T cell reactivity after COVID-19
This study analyzed whole blood samples (n = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2–derived antigens. Multimeric peptides spanning the entire nucleocapsid protein triggered strikingly synchronous formation of interleukin… Continue reading Transient and durable T cell reactivity after COVID-19
Eating Disorder Diagnoses in Children and Adolescents in Norway Before vs During the COVID-19 Pandemic
Studies from the US1,2 and Canada3,4 have reported increasing numbers of children and adolescents receiving treatment for eating disorders during the COVID-19 pandemic. Most patients are girls,1,2,4 and the predominant diagnosis is anorexia nervosa.1,2 There is insufficient information about the magnitude of this increase on a population level. In this cohort study, we analyzed trends… Continue reading Eating Disorder Diagnoses in Children and Adolescents in Norway Before vs During the COVID-19 Pandemic
Bacterial and fungal isolation from face masks under the COVID-19 pandemic
The COVID-19 pandemic has led people to wear face masks daily in public. Although the effectiveness of face masks against viral transmission has been extensively studied, there have been few reports on potential hygiene issues due to bacteria and fungi attached to the face masks. We aimed to (1) quantify and identify the bacteria and… Continue reading Bacterial and fungal isolation from face masks under the COVID-19 pandemic
Acute Disseminated Encephalomyelitis After SARS-CoV-2 Vaccination
BACKGROUND: Acute disseminated encephalomyelitis (ADEM) is a disorder of the central nervous system which has been associated with preceding infection as well as vaccinations. We present a case of a 61-year-old woman with ADEM after receiving her initial vaccination for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This case highlights management of this acute… Continue reading Acute Disseminated Encephalomyelitis After SARS-CoV-2 Vaccination
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