Objective To characterise the clinical features of monkeypox infection in humans.Design Descriptive case series.Setting A regional high consequences infectious disease centre with associated primary and secondary care referrals, and affiliated sexual health centres in south London between May and July 2022.Participants 197 patients with polymerase chain reaction confirmed monkeypox infection.Results The median age of participants… Continue reading Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series
Tag: transmission
Transmissibility of SARS-CoV-2 among fully vaccinated individuals
Vaccine effectiveness studies have conclusively demonstrated the benefit of COVID-19 vaccines in reducing individual symptomatic and severe disease, resulting in reduced hospitalisations and intensive care unit admissions.1 However, the impact of vaccination on transmissibility of SARS-CoV-2 needs to be elucidated. A prospective cohort study in the UK by Anika Singanayagam and colleagues2 regarding community transmission… Continue reading Transmissibility of SARS-CoV-2 among fully vaccinated individuals
COVID-19 trends and severity among symptomatic children aged 0 to 17 years in ten EU countries, 3 August 2020 to 3 October 2021
To guide evidence-based prevention of COVID-19 in children, we estimated risks of severe outcomes in 820,404 symptomatic paediatric cases reported by 10 EU Member States between August 2020 and October 2021. Case and hospitalisation rates rose as overall transmission increased but severe outcomes were rare: 9,611 (1.2%) were hospitalised, 640 (0.08%) required intensive care and… Continue reading COVID-19 trends and severity among symptomatic children aged 0 to 17 years in ten EU countries, 3 August 2020 to 3 October 2021
Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study
The SARS-CoV-2 delta (B.1.617.2) variant is highly transmissible and spreading globally, including in populations with high vaccination rates. We aimed to investigate transmission and viral load kinetics in vaccinated and unvaccinated individuals with mild delta variant infection in the community. MethodsBetween Sept 13, 2020, and Sept 15, 2021, 602 community contacts (identified via the UK… Continue reading Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study
Transmission of SARS-CoV-2 Delta Variant Among Vaccinated Healthcare Workers, Vietnam
Background: Data on breakthrough SARS-CoV-2 Delta variant infections are limited. Methods: We studied breakthrough infections among healthcare workers of a major infectious diseases hospital in Vietnam. We collected demographics, vaccination history and results of PCR diagnosis alongside clinical data. We measured SARS-CoV-2 (neutralizing) antibodies at diagnosis, and at week 1, 2 and 3 after diagnosis.… Continue reading Transmission of SARS-CoV-2 Delta Variant Among Vaccinated Healthcare Workers, Vietnam
Transmission of community- and hospital-acquired #SARS-CoV-2 in hospital settings in the UK: A cohort study
Nosocomial spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been widely reported, but the transmission pathways among patients and healthcare workers (HCWs) are unclear. Identifying the risk factors and drivers for these nosocomial transmissions is critical for infection prevention and control interventions. The main aim of our study was to quantify the relative… Continue reading Transmission of community- and hospital-acquired #SARS-CoV-2 in hospital settings in the UK: A cohort study
#COVID-19 Transmission Dynamics Among Close #Contacts of Index Patients With COVID-19A Population-Based Cohort Study in Zhejiang Province, China
Much remains unknown about the transmission dynamics of COVID-19. How the severity of the index case and timing of exposure is associated with disease in close contacts of index patients with COVID-19 and clinical presentation in those developing disease is not well elucidated. Objectives To investigate the association between the timing of exposure and development… Continue reading #COVID-19 Transmission Dynamics Among Close #Contacts of Index Patients With COVID-19A Population-Based Cohort Study in Zhejiang Province, China
Quantifying asymptomatic infection and transmission of #COVID-19 in New York City using observed cases, serology, and testing capacity
The contributions of asymptomatic infections to herd immunity and community transmission are key to the resurgence and control of COVID-19, but are difficult to estimate using current models that ignore changes in testing capacity. Using a model that incorporates daily testing information fit to the case and serology data from New York City, we show… Continue reading Quantifying asymptomatic infection and transmission of #COVID-19 in New York City using observed cases, serology, and testing capacity
#SARS-CoV-2 seroprevalence and #transmission risk factors among high-risk close contacts: a retrospective cohort study
The proportion of asymptomatic carriers and transmission risk factors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among household and non-household contacts remains unclear. In Singapore, extensive contact tracing by the Ministry of Health for every diagnosed COVID-19 case, and legally enforced quarantine and intensive health surveillance of close contacts provided a rare opportunity to… Continue reading #SARS-CoV-2 seroprevalence and #transmission risk factors among high-risk close contacts: a retrospective cohort study
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