Editor’s summaryTau pathology is a common denominator for neurodegenerative diseases such as Alzheimer’s disease or frontotemporal dementia, but selectively targeting toxic tau remains a challenge. Here, Gaikwad et al. developed a conformation-specific antibody for tau and demonstrated selective targeting of toxic tau aggregates in patient-derived tissue and tau oligomers in vitro. Packed into lipophile micelles, the antibody… Continue reading Nasal tau #immunotherapy clears intracellular #tau pathology and improves cognitive functions in aged tauopathy mice
Tag: Tau
Dietary #salt promotes cognitive impairment through tau phosphorylation
Dietary habits and vascular risk factors promote both #Alzheimer’s disease and cognitive impairment caused by vascular factors. Furthermore, accumulation of hyperphosphorylated tau, a microtubule-associated protein and a hallmark of Alzheimer’s pathology, is also linked to vascular cognitive impairment. In mice, a salt-rich diet leads to cognitive dysfunction associated with a nitric oxide deficit in cerebral… Continue reading Dietary #salt promotes cognitive impairment through tau phosphorylation
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