Key PointsQuestion Do patients with large joint replacements have elevated levels of arthroplasty-relevant metals in blood and cerebrospinal fluid (CSF)?Findings This cross-sectional study with 204 patients found blood levels of cobalt, chromium, titanium, niobium, and zirconium to be significantly higher in patients with large joint replacements compared with arthroplasty-naive control participants. Cobalt levels in CSF… Continue reading #Metal Concentrations in #Blood and #Cerebrospinal Fluid of Patients With #Arthroplasty Implants
Tag: arthroplasty
Effect of #denosumab on osteolytic lesion activity after total #hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial
Osteolysis causes recurrent pain and disability after total hip arthroplasty. We investigated the effect of the human monoclonal antibody denosumab on osteolytic lesion activity in patients undergoing revision total hip arthroplasty surgery to show the biological proof of concept for a non-surgical treatment for the disease.. Findings Between Dec 12, 2012, and June 24, 2018,… Continue reading Effect of #denosumab on osteolytic lesion activity after total #hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial
Acute #kidney injury after primary total hip #arthroplasty: a risk multiplier for complication, mortality, and healthcare utilization
To assess whether acute kidney injury (AKI) is associated with more complications and higher healthcare utilization in people undergoing primary total hip arthroplasty (THA).. ..Adjusted for age, gender, race, income, underlying diagnosis, medical comorbidity, and the insurance payer, AKI in people who underwent primary THA was associated with significantly higher OR (95% CI) of (1)… Continue reading Acute #kidney injury after primary total hip #arthroplasty: a risk multiplier for complication, mortality, and healthcare utilization
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