Motivated by a new randomized trial (the PEPTIC trial) that raised the issue of an increase in mortality with proton pump inhibitors (PPIs) relative to histamine-2 receptor antagonists (H2RAs), we updated our prior systematic review and network meta-analysis (NMA) addressing the impact of pharmacological gastrointestinal bleeding prophylaxis in critically ill patients. Seventy-four trials enrolling 39… Continue reading Efficacy and safety of gastrointestinal #bleeding prophylaxis in critically #ill patients: an updated systematic review and network meta-analysis of randomized trials
Tag: PPI
Association Between Acute #Gastroenteritis and Continuous Use of Proton Pump Inhibitors During Winter Periods of Highest Circulation of Enteric Viruses
An increased risk of acute bacterial enteric infections has been reported among patients receiving proton pump inhibitor (#PPI) therapy. The risk of acute gastroenteritis (AGE) of viral origin associated with continuous PPI exposure has been less studied ..At least 1 AGE epidemic episode was identified in 3131 patients (1.3%) receiving PPI therapy and in 4327… Continue reading Association Between Acute #Gastroenteritis and Continuous Use of Proton Pump Inhibitors During Winter Periods of Highest Circulation of Enteric Viruses
Randomized Trial of Medical versus Surgical Treatment for Refractory #Heartburn
..Heartburn that persists despite proton-pump inhibitor ( #PPI ) treatment is a frequent clinical problem with multiple potential causes. Treatments for PPI-refractory heartburn are of unproven efficacy and focus on controlling gastroesophageal reflux with reflux-reducing medication (e.g., baclofen) or antireflux surgery or on dampening visceral hypersensitivity with neuromodulators (e.g., desipramine). Prerandomization procedures excluded 288 patients:… Continue reading Randomized Trial of Medical versus Surgical Treatment for Refractory #Heartburn
