Key Points Question What are the effects of ketamine on belief updating in patients with treatment-resistant depression (TRD)? Findings This case-control study in patients with TRD showed that belief updating became more optimistically biased as soon as 4 hours after a first ketamine infusion. This early cognitive effect of ketamine was formalized by stronger asymmetrical reinforcement learning… Continue reading Evaluation of Early Ketamine Effects on Belief-Updating Biases in Patients With Treatment-Resistant Depression
Tag: Ketamine
Intranasal ketamine for acute cluster headache attacks—Results from a proof-of-concept open-label trial
ObjectiveTo investigate the safety and efficacy of intranasal ketamine for the treatment of a single cluster headache (CH) attack. BackgroundAcute treatment options for patients with CH who have an insufficient response to oxygen and triptans are limited. Intranasal ketamine has anecdotally been successful in treating a CH attack. MethodsWe conducted an open-label pilot study enrolling… Continue reading Intranasal ketamine for acute cluster headache attacks—Results from a proof-of-concept open-label trial
Acute cognitive effects of single-dose intravenous #ketamine in major #depressive and posttraumatic stress disorder
Intravenous (IV) subanesthetic doses of ketamine have been shown to reduce psychiatric distress in both major depressive (MDD) and posttraumatic stress disorder (PTSD). However, the effect of ketamine on cognitive function in these disorders is not well understood. To address this gap, we examined the effect of a single dose of IV ketamine on cognition… Continue reading Acute cognitive effects of single-dose intravenous #ketamine in major #depressive and posttraumatic stress disorder
A Randomized Controlled Trial of Repeated #Ketamine Administration for Chronic Posttraumatic Stress Disorder
Posttraumatic stress disorder (PTSD) is a chronic and disabling disorder, for which available pharmacotherapies have limited efficacy. The authors’ previous proof-of-concept randomized controlled trial of single-dose intravenous ketamine infusion in individuals with PTSD showed significant and rapid PTSD symptom reduction 24 hours postinfusion. The present study is the first randomized controlled trial to test the… Continue reading A Randomized Controlled Trial of Repeated #Ketamine Administration for Chronic Posttraumatic Stress Disorder
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