Tag: LPS

The physicochemical properties of #lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation

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Lipopolysaccharide (LPS) is the primary pathogenic factor in Gram-negative sepsis. While the presence of LPS in the bloodstream during infection is associated with disseminated intravascular coagulation, the mechanistic link between LPS and blood coagulation activation remains ill-defined. The contact pathway of coagulation—a series of biochemical reactions that initiates blood clotting when plasma factors XII (FXII)… Continue reading The physicochemical properties of #lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation