The current opioid epidemic necessitates a better understanding of human addiction neurobiology to develop efficacious treatment approaches. Here, we perform genome-wide assessment of chromatin accessibility of the human striatum in heroin users and matched controls. Our study reveals distinct neuronal and non-neuronal epigenetic signatures, and identifies a locus in the proximity of the gene encoding… Continue reading Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for #heroin use disorder
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