Few prospective studies have assessed the safety of direct oral anticoagulants (DOACs) in elective endoscopy. Our primary aim was to compare the risks of endoscopy-related gastrointestinal bleeding and thromboembolic events in patients on DOACs or vitamin K antagonists (VKAs) in this setting. Secondarily, we examined the impact of the timing of anticoagulant resumption on the… Continue reading #Endoscopy-related #bleeding and thromboembolic events in patients on direct oral anticoagulants or vitamin K antagonists
Tag: bleeding
Efficacy and safety of gastrointestinal #bleeding prophylaxis in critically #ill patients: an updated systematic review and network meta-analysis of randomized trials
Motivated by a new randomized trial (the PEPTIC trial) that raised the issue of an increase in mortality with proton pump inhibitors (PPIs) relative to histamine-2 receptor antagonists (H2RAs), we updated our prior systematic review and network meta-analysis (NMA) addressing the impact of pharmacological gastrointestinal bleeding prophylaxis in critically ill patients. Seventy-four trials enrolling 39… Continue reading Efficacy and safety of gastrointestinal #bleeding prophylaxis in critically #ill patients: an updated systematic review and network meta-analysis of randomized trials
Timing of #Endoscopy for Acute Upper Gastrointestinal #Bleeding
To evaluate whether urgent endoscopy improves outcomes in patients predicted to be at high risk for further bleeding or death, we randomly assigned patients with overt signs of acute upper gastrointestinal bleeding and a Glasgow–Blatchford score of 12 or higher (scores range from 0 to 23, with higher scores indicating a higher risk of further… Continue reading Timing of #Endoscopy for Acute Upper Gastrointestinal #Bleeding
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