Tag: leukemia

#Artificial #intelligence in #myeloid malignancies: Clinical applications of machine learning in myelodysplastic syndromes and acute myeloid #Leukemia

aledopress

This review summarizes applications of machine learning (ML) in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), spanning diagnosis, prognostication, treatment prediction, and research tools. In diagnostics, deep learning applied to bone marrow smears, peripheral blood films, and flow cytometry has shown high sensitivity and specificity, outperforming conventional methods. ML-driven unsupervised clustering and consensus classification… Continue reading #Artificial #intelligence in #myeloid malignancies: Clinical applications of machine learning in myelodysplastic syndromes and acute myeloid #Leukemia

Vitamin #B6 Addiction in Acute Myeloid #Leukemia

aledopress

Cancer cells rely on altered metabolism to support abnormal proliferation. We performed a CRISPR/Cas9 functional genomic screen targeting metabolic enzymes and identified PDXK—an enzyme that produces pyridoxal phosphate (PLP) from vitamin B6—as an acute myeloid leukemia (AML)-selective dependency.. PDXK kinase activity is required for PLP production and AML cell proliferation, and pharmacological blockade of the… Continue reading Vitamin #B6 Addiction in Acute Myeloid #Leukemia