Highlights• Elevated retinal homocysteine is a pathogenic feature of glaucoma• One-carbon metabolism is dysregulated in glaucoma• Oral B6, B9, B12, and choline is neuroprotective in animal modelsSummaryGlaucoma, characterized by the loss of retinal ganglion cells (RGCs), is a leading cause of blindness for which there are no neuroprotective therapies. To explore observations of elevated homocysteine… Continue reading Dysfunctional one-carbon metabolism identifies #vitamins B6, B9, B12, and choline as neuroprotective in #glaucoma
Tag: glaucoma
Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
Glaucoma, a leading cause of irreversible blindness, is a highly heritable human disease. Previous genome-wide association studies have identified over 100 loci for the most common form, primary open-angle glaucoma. Two key glaucoma-associated traits also show high heritability: intraocular pressure and optic nerve head excavation damage quantified as the vertical cup-to-disc ratio. Here, since much… Continue reading Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
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