#EPA and #DHA differentially modulate monocyte #inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study

The independent effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on chronic inflammation through their downstream lipid mediators, including the specialized pro-resolving lipid mediators (SPM), remain unstudied. Therefore, we compared the effects of EPA and DHA supplementation on monocyte inflammatory response and plasma polyunsaturated fatty acids (PUFA) SPM lipidome.. After a 4-week lead-in phase …

Continue reading #EPA and #DHA differentially modulate monocyte #inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study

Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells

Dietary lipids impact development, homeostasis, and disease, but links between specific dietary fats and cell fates are poorly understood. Ferroptosis is an iron-dependent form of nonapoptotic cell death associated with oxidized polyunsaturated phospholipids. Here, we show that dietary ingestion of the polyunsaturated fatty acid (PUFA) dihomogamma-linolenic acid (DGLA; 20:3n-6) can trigger germ-cell ferroptosis and sterility …

Continue reading Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells

Dietary #Sugars Alter Hepatic #Fatty Acid #Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins

Highlights • Addition of fructose to a high-fat diet increases hepatic malonyl-CoA more than glucose •Knockdown of the fructose metabolizing gene ketohexokinase increases CTP1a levels •Fructose supplementation alters mitochondrial size and function •Dietary fructose induces acetylation of ACADL and CPT1a to modify fat oxidation In summary, dietary fructose, but not glucose, supplementation of HFD impairs …

Continue reading Dietary #Sugars Alter Hepatic #Fatty Acid #Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins