Loss of Paneth cells and their antimicrobial granules compromises the intestinal epithelial barrier and is associated with Crohn’s disease, a major type of inflammatory bowel disease. Non-classical lymphoid cells, broadly referred to as intraepithelial lymphocytes (IELs), intercalate the intestinal epithelium. This anatomical position has implicated them as first-line defenders in resistance to infections, but their… Continue reading The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death
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