Evaluating the number of unvaccinated people needed to exclude to prevent SARS-CoV-2 transmissions

Vaccine mandates and vaccine passports (VMVP) for SARS-CoV-2 are thought to be a path out of the pandemic by increasing vaccination through coercion and excluding unvaccinated people from different settings because they are viewed as being at significant risk of transmitting SARS-CoV-2. While variants and waning efficacy are relevant, SARS-CoV-2 vaccines reduce the risk of …

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FGF1 and insulin control lipolysis by convergent pathways

Highlights•FGF1-FGFR1 signaling suppresses adipose lipolysis to curb hepatic glucose production•FGF1 suppresses lipolysis by inhibiting cAMP/PKA axis via PDE4D-S44 phosphorylation•Overexpression of PDE4D in the adipose tissue of diabetic mice corrects hyperglycemia•FGF1/PDE4D antilipolytic pathway is responsive to fed/fast states SummaryInexorable increases in insulin resistance, lipolysis, and hepatic glucose production (HGP) are hallmarks of type 2 diabetes. Previously, …

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