Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial

Randomized clinical trials have shown that aerobic exercise attenuates motor symptom progression in Parkinson's disease, but the underlying neural mechanisms are unclear. Here, we investigated how aerobic exercise influences disease-related functional and structural changes in the cortico-striatal sensorimotor network, which is involved in the emergence of motor deficits in Parkinson's disease. Additionally, we explored effects …

Continue reading Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial

Early estimates of SARS-CoV-2 Omicron variant severity based on a matched cohort study, Ontario, Canada

While it is now evident that Omicron is rapidly replacing Delta, largely due to immune escape, it is less clear how the severity of Omicron compares to Delta. In Ontario, we sought to examine hospitalization and death associated with Omicron, as compared to cases infected with Delta. We conducted a matched cohort study, considering time …

Continue reading Early estimates of SARS-CoV-2 Omicron variant severity based on a matched cohort study, Ontario, Canada