A novel peripheral biomarker for depression and antidepressant response

In contrast to healthy controls, the heterotrimeric G protein, Gsalpha (GsΞ±) is ensconced predominantly in lipid rafts in subjects with major depressive disorder (MDD) resulting in impaired stimulation of adenylyl cyclase. In this small proof-of-concept study, we examined the hypothesis that translocation of GsΞ± from lipid rafts toward a more facile activation of adenylyl cyclase …

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Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers

Janus kinase (JAK) inhibitors have shown encouraging results in the treatment of alopecia areata (AA), an autoimmune form of hair loss, in small, uncontrolled studies and case reports. ObjectiveWe conducted a biopsy substudy during the randomized, double-blind, placebo-controlled first 24 weeks of a phase 2a clinical trial that evaluated the efficacy and safety of ritlecitinib, …

Continue reading Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers