Are biomechanics during gait associated with the structural disease onset and progression of lower limb osteoarthritis? A systematic review and meta-analysis

To evaluate if gait biomechanics are associated with increased risk of structurally diagnosed disease onset or progression of lower limb osteoarthritis (OA). MethodA systematic review of Medline and Embase was conducted from inception to July 2021. Two reviewers independently screened records, extracted data and assessed risk of bias. Included studies reported gait biomechanics at baseline, …

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Free fatty-acid transport via CD36 drives Ξ²-oxidation-mediated hematopoietic stem cell response to infection

Acute infection is known to induce rapid expansion of hematopoietic stem cells (HSCs), but the mechanisms supporting this expansion remain incomplete. Using mouse models, we show that inducible CD36 is required for free fatty acid uptake by HSCs during acute infection, allowing the metabolic transition from glycolysis towards Ξ²-oxidation. Mechanistically, high CD36 levels promote FFA …

Continue reading Free fatty-acid transport via CD36 drives Ξ²-oxidation-mediated hematopoietic stem cell response to infection