Variation in common laboratory test results caused by ambient temperature

Highlights•Analysis of a dataset of nearly 5 million and over 200 million laboratory test results •Ambient temperature on the day an individual’s blood was drawn affected the test result •Affected assays included renal function tests, complete blood count, and lipid panels •Doctors prescribed fewer statins to individuals whose lipids were checked on colder days. Context …

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Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA

Flu defense via lung-resident IgA+ memory B cellsSecretory IgA antibody is known to be a key effector molecule in establishing effective antiviral immunity in the lungs, but the specific cell types producing this mucosal IgA and their physical locations are unclear. Oh et al. analyzed pulmonary IgA-secreting cells in mice after prior influenza infection or …

Continue reading Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA