Hypoglycemia associated with direct-acting anti-hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS)

Hypoglycemia induced by direct-acting antiviral agents (DAAs) for chronic hepatitis C virus (HCV) infection is a rare but potentially life-threatening adverse reaction, which led to warnings by competent authorities. We therefore aimed to examine the hypoglycemic safety signal for DAAs. MethodsReports to the US Food and Drug Administration Adverse Event Reporting System (FAERS) from 1 …

Continue reading Hypoglycemia associated with direct-acting anti-hepatitis C virus drugs: An epidemiologic surveillance study of the FDA adverse event reporting system (FAERS)

Mucosal immune response in BNT162b2 COVID-19 vaccine recipients

Although the BNT162b2 COVID-19 vaccine is known to induce IgG neutralizing antibodies in serum protecting against COVID-19, it has not been studied in detail whether it could generate specific immunity at mucosal sites, which represent the primary route of entry of SARS-CoV-2. MethodsSamples of serum and saliva of 60 BNT162b2-vaccinated healthcare workers were collected at …

Continue reading Mucosal immune response in BNT162b2 COVID-19 vaccine recipients

Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians

Type 2 Diabetes is a metabolic disorder characterized by hyperglycemia that causes numerous complications with significant long-term morbidity and mortality. The disorder is primarily due to insulin resistance particularly in liver, skeletal muscle, and adipose tissue. In this review, we detail the hormonal mechanisms leading to the development of diabetes and discuss whether intermittent fasting …

Continue reading Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians

Loving-kindness meditation slows biological aging in novices: Evidence from a 12-week randomized controlled trial

Highlightsโ€ขOver 12 weeks, loving-kindness meditation buffered telomere attrition. โ€ขTelomere length decreased in the mindfulness group and the control group. โ€ขThe loving-kindness group showed less telomere attrition than the control group. AbstractCombinations of multiple meditation practices have been shown to reduce the attrition of telomeres, the protective caps of chromosomes (Carlson et al., 2015). Here, we …

Continue reading Loving-kindness meditation slows biological aging in novices: Evidence from a 12-week randomized controlled trial

Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2

SARS-CoV-2-specific CD8+ T cells are scarce but detectable in unexposed healthy donors (UHDs). It remains unclear whether pre-existing human coronavirus (HCoV)-specific CD8+ T cells are converted to functionally competent T cells cross-reactive to SARS-CoV-2. Here, we identified the HLA-A24-high binding, immunodominant epitopes in SARS-CoV-2 spike region that can be recognized by seasonal coronavirus-specific CD8+ T …

Continue reading Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2