The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway

•Serum CCL-2 levels are lower in individuals with islet autoantibodies and type 1 diabetes compared to controls. •The 3p21.31 genetic locus is associated with type 1 diabetes. •Serum CCL-2 levels are associated with the 3p21.31 genetic locus. •The 3p21.31 genetic locus is associated with gene expression of the CCL-2 receptor, CCR2. AbstractMultiple cross-sectional and longitudinal …

Continue reading The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway

Thyroid as a target of adjuvant autoimmunity/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves’ disease to silent thyroiditis

BackgroundAs COVID-19 became a pandemic, the urgent need to find an effective treatment vaccine has been a major objective. Vaccines contain adjuvants which are not exempt from adverse effects and can trigger the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). There is very little information about autoimmune endocrine disease and the ASIA after the use of …

Continue reading Thyroid as a target of adjuvant autoimmunity/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves’ disease to silent thyroiditis