Microglial correlates of late life physical activity: Relationship with synaptic and cognitive aging in older adults

Physical activity relates to reduced dementia risk, though the cellular and molecular mechanisms are unknown. We translated animal and in-vitro studies demonstrating a causal link between physical activity and microglial homeostasis into humans. Decedents from Rush MAP completed actigraphy monitoring (average daily activity) and cognitive evaluation in life, and neuropathological examination at autopsy. Brain tissue …

Continue reading Microglial correlates of late life physical activity: Relationship with synaptic and cognitive aging in older adults

Metabolic Syndrome-Related Hyperuricemia is Associated with a Poorer Prognosis in Patients with Colorectal Cancer: A Multicenter Retrospective Study

Hyperuricemia and metabolic syndrome (MetS) have been shown to correlate with prognosis in patients with malignant tumors. The present study evaluated the relationship between preoperative hyperuricemia and MetS in colorectal cancer (CRC) patients and analyzed the effect of this combination on prognosis within 5 years. Patients and Methods: The study enrolled patients who had undergone …

Continue reading Metabolic Syndrome-Related Hyperuricemia is Associated with a Poorer Prognosis in Patients with Colorectal Cancer: A Multicenter Retrospective Study

Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral AΞ²-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study

Worldwide, coffee is one of the most popular beverages consumed. Several studies have suggested a protective role of coffee, including reduced risk of Alzheimer’s disease (AD). However, there is limited longitudinal data from cohorts of older adults reporting associations of coffee intake with cognitive decline, in distinct domains, and investigating the neuropathological mechanisms underpinning any …

Continue reading Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral AΞ²-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study

Face masks: benefits and risks during the COVID-19 crisis

The German government has made it mandatory to wear respiratory masks covering mouth and nose (MNC) as an effective strategy to fight SARS-CoV-2 infections. In many countries, this directive has been extended on shopping malls or public transportation. The aim of this paper is to critically analyze the statutory regulation to wear protective masks during …

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Autocrine vitamin #D signaling switches off pro-inflammatory programs of TH1 cells

The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1 helper T (TH1) cell responses remain poorly understood. Here we show that complement triggers contraction of TH1 responses by inducing intrinsic expression of the vitamin D (VitD) receptor and the VitD-activating enzyme CYP27B1, permitting T cells to both activate and respond to VitD. …

Continue reading Autocrine vitamin #D signaling switches off pro-inflammatory programs of TH1 cells