Impact of Sustained #Weight Loss on #Cardiometabolic Outcomes

Highlights•Sustained weight loss significantly lowers incidence of cardiometabolic outcomes.•Sustained weight loss significantly delays onset of cardiometabolic outcomes.•Greater weight loss significantly delays onset of cardiometabolic outcomes. Obesity increases the risk of developing type 2 diabetes, hypertension, and hyperlipidemia. We sought to determine the impact of obesity maintenance, weight regain, weight loss maintenance, and magnitudes of weight …

Continue reading Impact of Sustained #Weight Loss on #Cardiometabolic Outcomes

Identification of a choroid plexus vascular barrier closing during #intestinal inflammation

Locking down access to the brainInflammatory bowel disease is best known for intestinal symptoms but can also cause a variety of extraintestinal manifestations in other organs. It can also be associated with cognitive and psychiatric effects, including anxiety and depression. Using mouse models of intestinal inflammation, Carloni et al. uncovered a potential pathogenic link between …

Continue reading Identification of a choroid plexus vascular barrier closing during #intestinal inflammation

#Environmental risk factors and #cardiovascular diseases: a comprehensive expert review

AbstractNon-communicable diseases (NCDs) are fatal for more than 38 million people each year and are thus the main contributors to the global burden of disease accounting for 70% of mortality. The majority of these deaths are caused by cardiovascular disease (CVD). The risk of NCDs is strongly associated with exposure to environmental stressors such as …

Continue reading #Environmental risk factors and #cardiovascular diseases: a comprehensive expert review

Analysis of Respiratory #Fluoroquinolones and the Risk of Sudden #Cardiac Death Among Patients Receiving #Hemodialysis

Respiratory fluoroquinolone antibiotics are some of the most common medications with QT interval–prolonging potential prescribed to patients with hemodialysis-dependent kidney failure—individuals who have a very high risk of sudden cardiac death (SCD). To date, there have been no large-scale, population-specific studies evaluating the cardiac safety of respiratory fluoroquinolones in the hemodialysis population. Objective To investigate …

Continue reading Analysis of Respiratory #Fluoroquinolones and the Risk of Sudden #Cardiac Death Among Patients Receiving #Hemodialysis

#Nut consumption in association with overall mortality and recurrence/disease-specific mortality among long-term breast #cancer survivors

High nut consumption is associated with reduced total and certain cause-specific mortality in general populations. However, its association with cancer outcomes among long-term breast cancer survivors remains unknown. We examined the associations of nut consumption (including peanuts and tree nuts), assessed at 5-year postdiagnosis, with overall survival (OS) and disease-free survival (DFS) among 3449 long-term …

Continue reading #Nut consumption in association with overall mortality and recurrence/disease-specific mortality among long-term breast #cancer survivors