#Nafamostat–Interferon-α Combination Suppresses SARS-CoV-2 Infection In Vitro and In Vivo by Cooperatively Targeting Host TMPRSS2

SARS-CoV-2 and its vaccine/immune-escaping variants continue to pose a serious threat to public health due to a paucity of effective, rapidly deployable, and widely available treatments. Here, we address these challenges by combining Pegasys (IFNα) and nafamostat to effectively suppress SARS-CoV-2 infection in cell culture and hamsters. Our results indicate that Serpin E1 is an …

Continue reading #Nafamostat–Interferon-α Combination Suppresses SARS-CoV-2 Infection In Vitro and In Vivo by Cooperatively Targeting Host TMPRSS2

Long‐Term Exposure to Air #Pollution, Road #Traffic Noise, and #Heart Failure Incidence: The Danish Nurse Cohort

We examined the association of long‐term exposure to air pollution and road traffic noise with incident heart failure (HF). Methods And ResultsUsing data on female nurses from the Danish Nurse Cohort (aged >44 years), we investigated associations between 3‐year mean exposures to air pollution and road traffic noise and incident HF using Cox regression models, …

Continue reading Long‐Term Exposure to Air #Pollution, Road #Traffic Noise, and #Heart Failure Incidence: The Danish Nurse Cohort