Role of Adipocyte Na,K-ATPase Oxidant Amplification Loop in #Cognitive Decline and #Neurodegeneration

•Adipocytes induce phenotypical changes in neurodegeneration through adipocyte NKAL.•Adipocyte specific NaKtide inhibited NKAL and improved systemic homeostasis.•NaKtide improved adipocyte phenotype and improved markers of neurodegeneration.•NaKtide improved genomic profile of hippocampus and adipose tissue in WD fed mice. SummaryRecent studies suggest that a western diet may contribute to clinical neurodegeneration and dementia. Adipocyte-specific expression of the … Continue reading Role of Adipocyte Na,K-ATPase Oxidant Amplification Loop in #Cognitive Decline and #Neurodegeneration