#Probenecid inhibits #SARS-CoV-2 replication in vivo and in vitro

Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently blocks SARS-CoV-2 replication in mammalian cells and virus replication in a hamster model. Furthermore, we demonstrate …

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Effect of #Zuranolone vs Placebo in Postpartum #DepressionA Randomized Clinical Trial

Postpartum depression (PPD) is one of the most common medicalcomplications during and after pregnancy, negatively affecting both mother and child.OBJECTIVE To demonstrate the efficacy and safety of zuranolone, a neuroactive steroidΞ³-aminobutyric acid receptor–positive allosteric modulator, in PPD. DESIGN, SETTING, AND PARTICIPANTS This phase 3, double-blind, randomized, outpatient,placebo-controlled clinical trial was conducted between January 2017 and …

Continue reading Effect of #Zuranolone vs Placebo in Postpartum #DepressionA Randomized Clinical Trial