Two Phase 3 Trials of Inclisiran in Patients with Elevated #LDL Cholesterol

Inclisiran inhibits hepatic synthesis of proprotein convertase subtilisin–kexin type 9. Previous studies suggest that inclisiran might provide sustained reductions in low-density lipoprotein (LDL) cholesterol levels with infrequent dosing. METHODSWe enrolled patients with atherosclerotic cardiovascular disease (ORION-10 trial) and patients with atherosclerotic cardiovascular disease or an atherosclerotic cardiovascular disease risk equivalent (ORION-11 trial) who had elevated …

Continue reading Two Phase 3 Trials of Inclisiran in Patients with Elevated #LDL Cholesterol

#Ivermectin for Prevention and Treatment of #COVID-19Infection: A Systematic Review, Meta-analysis, and TrialSequential Analysis to Inform Clinical Guidelines

Background: Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasiticivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials. Areas of uncertainty: We assessed the efficacy of ivermectin treatment in reducing mortality, in secondary outcomes, and in chemoprophylaxis, among people with, or at high risk of, COVID-19 infection. …

Continue reading #Ivermectin for Prevention and Treatment of #COVID-19Infection: A Systematic Review, Meta-analysis, and TrialSequential Analysis to Inform Clinical Guidelines