#Intestinal barrier dysfunction plays an integral role in #arthritis pathology and can be targeted to ameliorate disease

HighlightsSerum gut-permeability markers LPB, LPS, and I-FABP are increased in RAMice with arthritis have increased gut permeability and intestinal inflammationBoth bacteria and leukocytes are needed to disrupt gut-barrier integrityPrevention of gut-barrier dysfunction in arthritis ameliorates joint inflammation Context and significanceRheumatoid arthritis is an autoimmune disorder characterized by chronic joint inflammation. Accumulating evidence suggests that changes …

Continue reading #Intestinal barrier dysfunction plays an integral role in #arthritis pathology and can be targeted to ameliorate disease

Vitamin #C and scar strength: analysis of a historical trial and implications for #collagen-related pathologies

A double-blind controlled trial initiated in 1944 has led to the common narrative that a 10-mg daily vitamin C intake is adequate to prevent and treat impaired wound healing, and by inference, other collagen-related diseases such as heart disease or stroke. The WHO relies on this narrative to set the recommended nutrient intake for vitamin …

Continue reading Vitamin #C and scar strength: analysis of a historical trial and implications for #collagen-related pathologies