High- #fat dietโ€“induced #colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide

A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut microbiota. However, whether diet-induced changes in intestinal physiology can alter the metabolic capacity of the microbiota remains unknown. Using a mouse model of diet-induced obesity, we show that chronic exposure to …

Continue reading High- #fat dietโ€“induced #colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide