The #sulfur microbial diet is associated with increased risk of early-onset #colorectal cancer precursors

Diet may contribute to the increasing incidence of colorectal cancer (CRC) before age 50 (early-onset CRC). Microbial metabolism of dietary sulfur produces hydrogen sulfide (H2S), a gastrointestinal carcinogen that cannot be easily measured at scale. As a result, evidence supporting its role in early neoplasia is lacking. MethodsWe evaluated long-term adherence to the sulfur microbial …

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Impaired local intrinsic immunity to SARS-CoV-2 infection in severe #COVID-19

SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals present with isolated upper respiratory symptoms, suggesting potential to constrain viral pathology to the nasopharynx. Which cells SARS-CoV-2 primarily targets and how infection influences the respiratory epithelium remains incompletely understood. We performed scRNA-seq on nasopharyngeal swabs from 58 healthy and COVID-19 participants. During COVID-19, we …

Continue reading Impaired local intrinsic immunity to SARS-CoV-2 infection in severe #COVID-19