#Metabolic responses to polychromatic #LED and #OLED light at night

Light exposure at night has various implications for human health, but little is known about its effects on energy metabolism during subsequent sleep. We investigated the effects of polychromatic white light using conventional light-emitting diodes (LED) and an alternative light source, organic light-emitting diodes (OLED), producing reduced spectral content in the short wavelength of blue …

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Immunotherapy-based targeting of MSLN+ activated portal #fibroblasts is a strategy for treatment of cholestatic liver #fibrosis

Mesothelin (Msln) expression is increased in tissue fibroblasts of damaged liver and other organs and Msln is a common mediator of liver, lung, and kidney fibrosis. We show that anti-Msln immunotoxins kill the Msln-expressing fibroblasts and reduce collagen type I deposition in fibrotic liver, indicating that agents that specifically kill Msln-expressing cells should be a …

Continue reading Immunotherapy-based targeting of MSLN+ activated portal #fibroblasts is a strategy for treatment of cholestatic liver #fibrosis