#COVID-19 #vaccine efficacy and effectiveness—the elephant (not) in the room

Approximately 96 COVID-19 vaccines are at various stages of clinical development.1 At present, we have the interim results of four studies published in scientific journals (on the Pfizer–BioNTech BNT162b2 mRNA vaccine,2 the Moderna–US National Institutes of Health [NIH] mRNA-1273 vaccine,3 the AstraZeneca–Oxford ChAdOx1 nCov-19 vaccine,4 and the Gamaleya GamCovidVac [Sputnik V] vaccine)5 and three studies …

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#Baricitinib reduces 30-day mortality in older adults with moderate-to-severe #COVID-19 pneumonia

Older adults are at the highest risk of severe disease and death due to COVID-19. Randomized data have shown that baricitinib improves outcomes in these patients, but focused stratified analyses of geriatric cohorts are lacking. Our objective was to analyze the efficacy of baricitinib in older adults with COVID-19 moderate-to-severe pneumonia. MethodsThis is a propensity …

Continue reading #Baricitinib reduces 30-day mortality in older adults with moderate-to-severe #COVID-19 pneumonia