Safety and Efficacy of amplitude-modulated radiofrequency electromagnetic fields in advanced #hepatocellular carcinoma

Importance: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Despite the recent approval of several new agents, long-term disease control remains elusive for most patients. Administration of 27.12 MHz radiofrequency (RF) electromagnetic fields (EMF) by means of a spoon-shaped antenna (TheraBionic P1 device) placed on the anterior part of the tongue …

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Evaluation of serum #calcium differences in #hypertensive crises and control patients: A randomly matched case-control study

The role of calcium in blood pressure has been widely studied among hypertensive patients; however, no study has explored the role of calcium in hypertensive crises. The primary objective of this study is to evaluate the differences in serum calcium levels between hypertensive crises patients and a 1:1 random matched controls (age-, sex-, race-, diabetes, …

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#Ejaculation Frequency and Risk of #Prostate Cancer: Updated Results with an Additional Decade of Follow-up

Evidence suggests that ejaculation frequency may be inversely related to the risk of prostate cancer (PCa), a disease for which few modifiable risk factors have been identified. ObjectiveTo incorporate an additional 10 yr of follow-up into an original analysis and to comprehensively evaluate the association between ejaculation frequency and PCa, accounting for screening, clinically relevant …

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Reinforcement learning links spontaneous cortical #dopamine impulses to reward

Extrasynaptic levels of dopamine in mouse cortex exhibit spontaneous impulses•Impulses are broadly distributed in amplitude and time, with a rate of about 0.01/s•Feedback was used to train mice to volitionally control their spontaneous impulses•Mice learned to reliably modulate dopamine impulses in order to receive a reward SummaryIn their pioneering study on dopamine release, Romo and …

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Long-term Dietary #Flavonoid Intake and Subjective #Cognitive Decline in US Men and Women

To prospectively examine the associations between long-term dietary flavonoids and subjective cognitive decline (SCD). Methods: We followed 49,493 women from the Nurses’ Health Study (NHS) (1984-2006) and 27,842 men from the Health Professionals Follow-up Study (HPFS) (1986-2002). Poisson regression was used to evaluate the associations between dietary flavonoids (flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, polymeric flavonoids, …

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