Dynamic innate immune response determines susceptibility to #SARS-CoV-2 infection and early replication kinetics

Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication levelcorrelates with the likelihood of viral transmission. Here, we examined the role of host innate immune defenses in restrictingearly SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples andexperiments with airway epithelial organoids. SARS-CoV-2 initially …

Continue reading Dynamic innate immune response determines susceptibility to #SARS-CoV-2 infection and early replication kinetics

The risk of ischemic #stroke and hemorrhagic stroke in Chinese adults with low-density lipoprotein #cholesterol concentrations < 70 mg/dL

The risk of stroke in individuals with very low low-density lipoprotein cholesterol (LDL-C) concentrations remains high. We sought to prioritize predictive risk factors for stroke in Chinese participants with LDL-C concentrations < 70 mg/dL using a survival conditional inference tree, a machine learning method. MethodsThe training dataset included 9327 individuals with LDL-C concentrations < 70 mg/dL who were free …

Continue reading The risk of ischemic #stroke and hemorrhagic stroke in Chinese adults with low-density lipoprotein #cholesterol concentrations < 70 mg/dL