#Homocysteine predicts vascular target organ damage in #hypertension and may serve as guidance for first-line antihypertensive therapy

Homocysteine is an independent risk factor for cardiovascular and cerebrovascular disease and has been proposed to contribute to vascular dysfunction. We sought to determine in a real-world clinical setting whether homocysteine levels were associated with hypertension mediated organ damage (HMOD) and could guide treatment choices in hypertension. We performed a cross-sectional analysis of prospectively collected …

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Multiple #SARS-CoV-2 variants escape neutralization by #vaccine-induced humoral immunity

Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines …

Continue reading Multiple #SARS-CoV-2 variants escape neutralization by #vaccine-induced humoral immunity