A phase 2 trial of inhaled #nitrous oxide for treatment-resistant major #depression

Laughing gas improves depressionAbout one-third of individuals suffering from depression are at risk for treatment resistance. Whereas inhaled 50% nitrous oxide has early antidepressant effects on individuals with treatment-resistant major depression (TRMD), adverse effects can occur at this concentration. In this phase 2 clinical trial, Nagele et al. studied the effects of a single 1-hour …

Continue reading A phase 2 trial of inhaled #nitrous oxide for treatment-resistant major #depression

#Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to #stress via regulation of FKBP5

Responding to different dynamic levels of stress is critical for mammalian survival. Disruption of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to underlie hypothalamic-pituitary-adrenal (HPA) axis dysregulation observed in stress-related psychiatric disorders. In this study, we show that FK506-binding protein 51 (FKBP5) plays a critical role in fine-tuning MR:GR balance in the …

Continue reading #Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to #stress via regulation of FKBP5