#Sleep difficulties, incident #dementia and all-cause mortality among older adults across 8 years: Findings from the National Health and Aging Trends Study

Sleep difficulties have been implicated in the development and progression of dementia and in all-cause mortality. This study examines the relationship between sleep difficulties, incident dementia and all-cause mortality over 8 years of follow-up among a nationally representative sample of older (≥65 years) adults in the United States. We used data collected from the National …

Continue reading #Sleep difficulties, incident #dementia and all-cause mortality among older adults across 8 years: Findings from the National Health and Aging Trends Study

Potential anti-COVID-19 agents, #cepharanthine and #nelfinavir, and their usage for combination treatment

Nelfinavir (NFV) inhibits SARS-CoV-2 replication•Cepharanthine (CEP) inhibits SARS-CoV-2 attachment to target cells•Combination of NFV and CEP can synergistically augment antiviral activity•NFV and CEP are estimated to shorten the time to viral elimination at clinical doses SummaryAntiviral treatments targeting the coronavirus disease 2019 are urgently required. We screened a panel of already approved drugs in a …

Continue reading Potential anti-COVID-19 agents, #cepharanthine and #nelfinavir, and their usage for combination treatment