Genetically Proxied Diurnal Preference, #Sleep Timing, and Risk of Major #Depressive Disorder

Morning diurnal preference is associated with reduced risk of major depressive disorder (MDD); however, causality in this association is uncertain. Objective To examine the association of genetically proxied morning diurnal preference with depression risk using mendelian randomization. Design, Setting, and Participants This 2-sample mendelian randomization study used summary-level genetic associations with diurnal preference and MDD. …

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#Mirtazapine in cancer-associated #anorexia and #cachexia: A double-blind placebo-controlled randomized trial

Few pharmacological interventions are available for cancer-associated anorexia and cachexia. Mirtazapine has been suggested for use in cancer-associated anorexia and cachexia. ObjectivesThis study was conducted to assess the efficacy and tolerability of mirtazapine in cancer-associated anorexia and cachexia. MethodsA double-blind placebo-controlled randomized trial. The study included 120 incurable solid tumour patients with anorexia (appetite loss …

Continue reading #Mirtazapine in cancer-associated #anorexia and #cachexia: A double-blind placebo-controlled randomized trial