Distinctive prognostic factor of heart #failure with preserved ejection fraction stratified with admission blood pressure

The prognostic importance of admission systolic blood pressure (SBP) in heart failure with preserved ejection fraction (HFpEF) is elusive. We aimed to clarify the pathophysiological differences between patients categorized with admission SBP among HFpEF patients. Methods and resultsWe studied 1008 inpatients from PURSUIT-HFpEF, a multicentre prospective observational registry. We classified patients as having elevated (>140 …

Continue reading Distinctive prognostic factor of heart #failure with preserved ejection fraction stratified with admission blood pressure

Depleting #plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous #lupus

Plasmacytoid dendritic cells (pDCs) not only are specialized in their capacity to secrete large amounts of type I interferon (IFN) but also serve to enable both innate and adaptive immune responses through expression of additional proinflammatory cytokines, chemokines, and costimulatory molecules. Persistent activation of pDCs has been demonstrated in a number of autoimmune diseases. To …

Continue reading Depleting #plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous #lupus