Association of #Mitochondrial Biogenesis With Variable Penetrance of #Schizophrenia

Discovery of mechanisms that underlie variable penetrance for neuropsychiatric illness in the context of genetic variants that carry elevated risk can advance novel treatment approaches for these disorders. Objective To test the hypothesis that mitochondrial compensation is associated with the variable penetrance of schizophrenia in the 22q11.2 deletion syndrome (22q11DS). Design, Setting, and Participants This …

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Associations of #cognitive performance with #cardiovascular magnetic resonance phenotypes in the UK Biobank

Existing evidence suggests links between brain and cardiovascular health. We investigated associations between cognitive performance and cardiovascular magnetic resonance (CMR) phenotypes in the UK Biobank, considering a range of potential confounders. Methods and resultsWe studied 29 763 participants with CMR and cognitive testing, specifically, fluid intelligence (FI, 13 verbal-numeric reasoning questions), and reaction time (RT, a …

Continue reading Associations of #cognitive performance with #cardiovascular magnetic resonance phenotypes in the UK Biobank