Peripheral-specific Y1 receptor antagonism increases #thermogenesis and protects against diet-induced #obesity

Obesity is caused by an imbalance between food intake and energy expenditure (EE). Here we identify a conserved pathway that links signalling through peripheral Y1 receptors (Y1R) to the control of EE. Selective antagonism of peripheral Y1R, via the non-brain penetrable antagonist BIBO3304, leads to a significant reduction in body weight gain due to enhanced …

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Mammalian enteral #ventilation ameliorates respiratory failure

Enteral ventilation (EVA) enabled systemic oxygenation in mammaliansEVA improved survival and behaviors in pre-clinical models of respiratory failureEVA yielded no major signs of complications in pre-clinical modelsEVA may serve as a transformative approach in respiratory failure patients Context and significanceThe SARS-CoV-2 pandemic has overwhelmed the clinical need for ventilators and artificial lungs, resulting in a …

Continue reading Mammalian enteral #ventilation ameliorates respiratory failure