SARS-CoV-2 #Spike Protein Impairs #Endothelial Function via Downregulation of ACE 2

... SARS-CoV-2 infection induces EC inflammation, leading to endotheliitis.1,5 Because S protein decreased ACE2 level and impaired NO bioavailability, we examined whether S protein entry is indispensable for dysfunctional endothelium. As shown in Figure [F], i, the endothelium-dependent vasodilation induced by acetylcholine was impaired in pulmonary arteries isolated from Pseu-Spike-administered hamsters, whereas the endothelium-independent vasodilation … Continue reading SARS-CoV-2 #Spike Protein Impairs #Endothelial Function via Downregulation of ACE 2