Genetic analysis in European ancestry individuals identifies 517 loci associated with #liver enzymes

Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank participants. Replication in 315,572 individuals from European descent from the Million Veteran Program, Rotterdam Study and Lifeline …

Continue reading Genetic analysis in European ancestry individuals identifies 517 loci associated with #liver enzymes

Mitigating the threat of emerging #infectious diseases; a coevolutionary perspective

β€œNothing in biology makes sense except in the light of evolution”[1] and this is no less true for viral pathogens than it is for their host species. To appreciate the full extent of the challenges posed by current and future emerging infectious diseases (EIDs), I believe it is insightful to take a coevolutionary perspective. Coevolution …

Continue reading Mitigating the threat of emerging #infectious diseases; a coevolutionary perspective